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KMID : 0370019980120000081
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Chung-Ang Journal of Pharmacal Sciences
1998 Volume.12 No. 0 p.81 ~ p.85
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Antimicrobial Activity of Bivalent Quinolone Carboxylic Acid Derivatives
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Abstract
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The synthesized bivalent ligand derivatives of enoxacin, norfloxacin, and pipemidic acid were evaluated for their antimicrobial activities, in vitro, against Escherichia coli (6-PE-4), klebsiella pneumoniae (JYA 78314), Bacillus subtilis (74-51), Proteus vulgais (78651), Staphylococcus aureus (HCA79110), and Pseudomonas aeruginosa (8765-1 P_2). Free carboxylic bivalent ligand derivatives (1-12) showed similar activities to their parent quinolone carboxylic acids (enoxacin, norfloxacin, and pipemidic acid) and pivaloyloxymethyl ester analogues (13-24) have little stronger activities than free carboxylic bivalent ligand derivatives (1-12). Bivalent ligand derivatives of oxalyl and malonyl analogues showed stronger activities than those of fumaryl and succinyl analogues.
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